Abiraterone Acetate InterMediate
17-Iodoandrosta-5,16-dien-3beta-acetate ester
CAS: 114611-53-9
Molecular Formula: C21H29IO2
Abiraterone Acetate InterMediate - Names and Identifiers
| Name | 17-Iodoandrosta-5,16-dien-3beta-acetate ester |
| Synonyms | Abiraterone Acetate InterMediate 17-Iodoandrosta-5,16-dien-3β-acetate ester 17-Iodoandrosta-5,16-dien-3beta-ol 3-acetate 17-Iodoandrosta-5,16-dien-3beta-acetate ester (3beta)-17-iodo-Androsta-5,16-dien-3-ol 3-acetate Androsta-5,16-dien-3-ol, 17-iodo-, 3-acetate, (3β)- (3S,8R,9S,10R,13S,14S)-17-Iodo-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyc [(3S,8R,9S,10R,13S,14S)-17-iodo-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate (3S,8R,9S,10R,13S,14S)-17-Iodo-10,13-diMethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate |
| CAS | 114611-53-9 |
| InChI | InChI=1S/C21H29IO2/c1-13(23)24-15-8-10-20(2)14(12-15)4-5-16-17-6-7-19(22)21(17,3)11-9-18(16)20/h4,7,15-18H,5-6,8-12H2,1-3H3/t15?,16?,17?,18?,20-,21-/m0/s1/i22+18 |
Abiraterone Acetate InterMediate - Physico-chemical Properties
| Molecular Formula | C21H29IO2 |
| Molar Mass | 440.36 |
| Density | 1.41 |
| Boling Point | 455.8±45.0 °C(Predicted) |
| Storage Condition | 2-8°C |
| Sensitive | Irritant |
| MDL | MFCD23115720 |
Abiraterone Acetate InterMediate - Reference Information
| use | 17-iodoandrosterone -5,16-diene-3BETA-alcohol acetate is the preparation intermediate of abiraterone acetate. In 2011, FDA approved abiraterone acetate oral tablets to be listed under the trade name ZYTIGA. Abiraterone acetate is converted into abiraterone in vivo. Abiraterone is an inhibitor of male hormone synthesis, which can inhibit 17 α-hydroxylase/C17,20-lyase (CYP17), which is in the testis, adrenal glands and prostate tumor tissues. Expression in. Metastatic castration-resistant prostate cancer in patients who had previously received docetaxel chemotherapy is clinically treated by combination of abiraterone acetate and prednisone. |
Last Update：2024-04-09 15:16:42
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